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27 Health and Nutrition Tips That Are Actually Evidence-Based

here is a lot of confusion when it comes to health and nutrition.

People, even qualified experts, often seem to have the exact opposite opinions.

However, despite all the disagreements, there are a few things that are well supported by research.

Here are 27 health and nutrition tips that are actually based on good science.

1. Don't Drink Sugar Calories
Sugary drinks are the most fattening things you can put into your body.

This is because liquid sugar calories don't get registered by the brain in the same way as calories from solid foods (1).

For this reason, when you drink soda, you end up eating more total calories (2, 3).

Sugary drinks are strongly associated with obesity, type 2 diabetes, heart disease and all sorts of health problems (4, 5, 6, 7).

Keep in mind that fruit juices are almost as bad as soda in this regard. They contain just as much sugar, and the small amounts of antioxidants do NOT negate the harmful effects of the sugar (8).

2. Eat Nuts
Despite being high in fat, nuts are incredibly nutritious and healthy.

They are loaded with magnesium, vitamin E, fiber and various other nutrients (9).

Studies show that nuts can help you lose weight, and may help fight type 2 diabetes and heart disease (10, 11, 12).

Additionally, about 10-15% of the calories in nuts aren't even absorbed into the body, and some evidence suggests that they can boost metabolism (13).

In one study, almonds were shown to increase weight loss by 62% compared to complex carbohydrates (14).


3. Avoid Processed Junk Food (Eat Real Food Instead)
All the processed junk foods in the diet are the biggest reason the world is fatter and sicker than ever before.

These foods have been engineered to be "hyper-rewarding," so they trick our brains into eating more than we need, even leading to addiction in some people (15).

They are also low in fiber, protein and micronutrients (empty calories), but high in unhealthy ingredients like added sugar and refined grains.

4. Don't Fear Coffee
Coffee has been unfairly demonized. The truth is that it's actually very healthy.

Coffee is high in antioxidants, and studies show that coffee drinkers live longer, and have a reduced risk of type 2 diabetes, Parkinson's disease, Alzheimer's and numerous other diseases (16, 17, 18, 19, 20, 21).


5. Eat Fatty Fish
Pretty much everyone agrees that fish is healthy.

This is particularly true of fatty fish, like salmon, which is loaded with omega-3 fatty acids and various other nutrients (22).

Studies show that people who eat the most fish have a lower risk of all sorts of diseases, including heart disease, dementia and depression (23, 24, 25).


6. Get Enough Sleep
The importance of getting enough quality sleep can not be overstated.

It may be just as important as diet and exercise, if not more.

Poor sleep can drive insulin resistance, throw your appetite hormones out of whack and reduce your physical and mental performance (26, 27, 28, 29).

What's more, it is one of the strongest individual risk factors for future weight gain and obesity. One study showed that short sleep was linked to 89% increased risk of obesity in children, and 55% in adults (30).

7. Take Care of Your Gut Health With Probiotics and Fiber
The bacteria in your gut, collectively called the gut microbiota, are sometimes referred to as the "forgotten organ."

These gut bugs are incredibly important for all sorts of health-related aspects. A disruption in the gut bacteria is linked to some of the world's most serious chronic diseases, including obesity (31, 32).

A good way to improve gut health, is to eat probiotic foods (like live yogurt and sauerkraut), take probiotic supplements, and eat plenty of fiber. Fiber functions as fuel for the gut bacteria (33, 34).

8. Drink Some Water, Especially Before Meals
Drinking enough water can have numerous benefits.

One important factor, is that it can help boost the amount of calories you burn.

According to 2 studies, it can boost metabolism by 24-30% over a period of 1-1.5 hours. This can amount to 96 additional calories burned if you drink 2 liters (67 oz) of water per day (35, 36).

The best time to drink water is half an hour before meals. One study showed that half a liter of water, 30 minutes before each meal, increased weight loss by 44% (37).

9. Don't Overcook or Burn Your Meat
Meat can be a nutritious and healthy part of the diet. It is very high in protein, and contains various important nutrients.

The problems occur when meat is overcooked and burnt. This can lead to the formation of harmful compounds that raise the risk of cancer (38).

So, eat your meat, just don't overcook or burn it.

10. Avoid Bright Lights Before Sleep
When we're exposed to bright lights in the evening, this disrupts production of the sleep hormone melatonin (39, 40).

An interesting "hack" is to use a pair of amber-tinted glasses that block blue light from entering your eyes in the evening.

This allows melatonin to be produced as if it were completely dark, helping you sleep better (41, 42).

11. Take Vitamin D3 If You Don't Get Much Sun
Back in the day, most people got their vitamin D from the sun.

The problem is that most people don't get much sun these days. They either live where there is no sun, or they stay inside most of the day or use sunscreen when they go out.

According to data from 2005-2006, about 41.6% of the US population is deficient in this critical vitamin (43).

If adequate sun exposure is not an option for you, then supplementing with vitamin D has been shown to have numerous benefits for health.

This includes improved bone health, increased strength, reduced symptoms of depression and a lower risk of cancer, to name a few. Vitamin D may also help you live longer (44, 45, 46, 47, 48, 49, 50).

12. Eat Vegetables and Fruits
Vegetables and fruits are the "default" health foods, and for good reason.

They are loaded with prebiotic fiber, vitamins, minerals and all sorts of antioxidants, some of which have potent biological effects.

Studies show that people who eat the most vegetables and fruits live longer, and have a lower risk of heart disease, type 2 diabetes, obesity and all sorts of diseases (51, 52).

13. Make Sure to Eat Enough Protein
Eating enough protein is incredibly important, and many experts believe that the recommended daily intake is too low.

Protein is particularly important for weight loss, and works via several different mechanisms (53).

A high protein intake can boost metabolism significantly, while making you feel so full that you automatically eat fewer calories. It can also cut cravings and reduce the desire for late-night snacking (54, 55, 56, 57).

Eating plenty of protein has also been shown to lower blood sugar and blood pressure levels (58, 59).

14. Do Some Cardio, or Just Walk More
Doing aerobic exercise (or cardio) is one of the best things you can do for your mental and physical health.

It is particularly effective at reducing belly fat, the harmful type of fat that builds up around your organs. Reduced belly fat should lead to major improvements in metabolic health (60, 61, 62).

15. Don't Smoke or do Drugs, and Only Drink in Moderation
If you're a tobacco smoker, or abuse drugs, then diet and exercise are the least of your worries. Tackle those problems first.

If you choose to include alcohol in your life, then do so in moderation only, and consider avoiding it completely if you have alcoholic tendencies.

16. Use Extra Virgin Olive Oil
Extra virgin olive oil is the healthiest fat on the planet.

It is loaded with heart-healthy monounsaturated fats and powerful antioxidants that can fight inflammation (63, 64, 65).

Extra virgin olive oil leads to many beneficial effects on heart health, and people who consume olive oil have a much lower risk of dying from heart attacks and strokes (66, 67).

17. Minimize Your Intake of Added Sugars
Added sugar is the single worst ingredient in the modern diet.

Small amounts are fine, but when people eat large amounts, it can wreak havoc on metabolic health (68).

A high intake of added sugar is linked to numerous diseases, including obesity, type 2 diabetes, heart disease and many forms of cancer (69, 70, 71, 72, 73).

18. Don't Eat a Lot of Refined Carbohydrates
Not all carbs are created equal.

Refined carbs have been highly processed, and have had all the fiber removed from them. They are low in nutrients (empty calories), and can be extremely harmful.

Studies show that refined carbohydrates are linked to overeating and numerous metabolic diseases (74, 75, 76, 77, 78).

19. Don't Fear Saturated Fat
The "war" on saturated fat was a mistake.

It is true that saturated fat raises cholesterol, but it also raises HDL (the "good") cholesterol and changes the LDL from small to large, which is linked to a lower risk of heart disease (79, 80, 81, 82).

New studies that included hundreds of thousands of people have shown that there is no link between saturated fat consumption and heart disease (83, 84).

20. Lift Heavy Things
Lifting weights is one of the best things you can do to strengthen your body and improve your body composition.

It also leads to massive improvements in metabolic health, including improved insulin sensitivity (85, 86).

The best approach is to go to a gym and lift weights, but doing body weight exercises can be just as effective.

21. Avoid Artificial Trans Fats
Artificial trans fats are harmful, man-made fats that are strongly linked to inflammation and heart disease (87, 88, 89, 90).

It is best to avoid them like the plague.

22. Use Plenty of Herbs and Spices
There are many incredibly healthy herbs and spices out there.

For example, ginger and turmeric both have potent anti-inflammatory and antioxidant effects, leading to various health benefits (91, 92, 93, 94).

You should make an effort to include as many different herbs and spices as you can. Many of them can have powerful beneficial effects on your health.

23. Take Care of Your Relationships
Social relationships are incredibly important. Not only for your mental wellbeing, but your physical health as well.

Studies show that people who are close with friends and family are healthier and live much longer than those who are not (95, 96, 97).

24. Track Your Food Intake Every Now and Then
The only way to know exactly what you are eating, is to weigh your foods and use a nutrition tracker like MyFitnesspal or Cron-o-meter.

This is important to know how many calories you are eating. It is also essential to make sure that you're getting in enough protein, fiber and micronutrients.

Studies show that people who track their food intake in one way or another tend to be more successful at losing weight and sticking to a healthy diet (98).

Basically, anything that increases your awareness of what you are eating is likely to help you succeed.

I personally track everything I eat for a few days in a row, every few months. Then I know exactly where to make adjustments in order to get closer to my goals.

25. If You Have Excess Belly Fat, Get Rid of it
Not all body fat is equal.

It is mostly the fat in your abdominal cavity, the belly fat, that causes problems. This fat builds up around the organs, and is strongly linked to metabolic disease (99, 100).

For this reason, your waist size may be a much stronger marker for your health than the number on the scale.

Cutting carbs, eating more protein, and eating plenty of fiber are all excellent ways to get rid of belly fat (101, 102, 103, 104).

This article lists 6 evidence-based ways to lose belly fat.

26. Don't go on a "Diet"
Diets are notoriously ineffective, and rarely work well in the long term.

In fact, "dieting" is one of the strongest predictors for future weight gain (105).

Instead of going on a diet, try adopting a healthier lifestyle. Focus on nourishing your body, instead of depriving it.

Weight loss should follow as a natural side effect of better food choices and improved metabolic health.

27. Eat Eggs, and Don't Throw Away The Yolk
Whole eggs are so nutritious that they're often referred to as "nature's multivitamin."

It is a myth that eggs are bad for you because of the cholesterol. Studies show that they have no effect on blood cholesterol in the majority of people (106).

Additionally, a massive review study that included 263,938 individuals found that egg consumption had no association with the risk of heart disease (107).

What we're left with is one of the most nutritious foods on the planet, and the yolk is where almost all of the nutrients are found.

Telling people to throw away the yolk is among the worst pieces of advice in the history of nutrition.

Heath Insurance

HOW TO GET HEALTH BENEFITS AND INSURANCE FOR YOUR BLOG

GOTTA HAVE IT...!

[This is part of the Escaping the 9-5: My Road to ProBlogging series.]

I’ve gotten this question a number of times since becoming a professional blogger and it makes sense, especially if you have a family to feed when you start on your little adventure to become a blogger full time.

Without health benefits in line I would never have really considered making a move from the 9-5 into ProBlogging!

Besides the obvious financial concerns that a blogger should have (which can be many, but just make sure you “stay in the black!”) there are other ones like health insurance and health benefits that you’re going to have to either forgo or figure out. Most people will attempt the latter and begin the process of getting some.

There are only so many options (that I’m aware of) and please don’t consider me an expert in this subject at all! In fact, hopefully this blog post will give an opportunity for the real professionals to step in and offer some counsel and advice as well.

But here’s what I did to get health benefits and health insurance as a blogger:



COBRA Insurance:
I knew that there were a couple of different options but I first started with COBRA which stands for The Consolidated Omnibus Budget Reconciliation Act and essentially it gives workers and their families continued group coverage and health benefits via their old employer.

For example, I left my full time job and continued to use their medical plan (called “continuation coverage”) for a bit even after I had left. Here are some things that I know about COBRA:

It’s not cheap, but it works and for continued coverage in a plan that you and your family needs it does the job.
Pricing is dependent on a number of different factors.
Stipulations, coverage, and cost can be gotten (typically) directly from your old employer.
You can find out more here at the U.S. Department of Labor website.


Personal Insurance:
Although I applied, was accepted, and started on COBRA I knew that it wouldn’t be the best option, especially from a financial perspective. I thus began my research into getting personal insurance through a national and/or local vendor.

To be sure, I was not a professional and didn’t have a clue where to get started, but I asked my personal network for advice, asked questions via Twitter, and got a slew of recommendations for services to try.

Ultimately I connected up with a very strong and trusted referral via my brother who had been doing the same type of research (and I’m sure there’s someone in your network who has done a lot of the legwork already and who can give you all this information!) and started working through her as a local broker for health insurance plans.

She did a great job and presented me with 2 quotes from different sources (Blue Cross Blue Shield of Georgia and Kaiser Permanente) breaking down all the benefits, structure, and costs.

I’ve provided a screenshot of that Microsoft Excel document that she gave me so you can get an idea of what it looked like:


IT WAS A VERY COMPREHENSIVE OUTLINE OF COSTS, BENEFITS, ETC.

As you can see it was a very robust document and my health insurance broker (email me if you’d like her contact info, she is the best!) broke it down and then I made a decision.

For a general overview the plans were very similar with one offering a bit more here and there than the other. The cost wasn’t too big of a difference either and I opted for BlueCross BlueShield in the end.

Despite the $900 price tag it was still $6 or $700 dollars cheaper than COBRA so I was doing alright in my book. And, the biggest factor was that my previous employer’s health insurance was BCBS of GA as well so our coverage wouldn’t change really at all and we could keep all the same doctors and physicians that we had already invested time and emotion into (and who we trusted).

So that’s what we went with, BCBS of GA with Health, Vision, and Dental coverage. I’m a very happy customer!


Small Business Insurance (for 2+ Bloggers):
The final option which I also began research in earnest was getting small business insurance for my startups and personal LLCs. At some point I will offer health insurance to my team and wanted to see if establishing that now would be beneficial for myself financially and my partners as a solution as well.

As it relates to blogs and being a blogger at some point you might also want to consider C/S-Corp or going the LLC (Limited Liability Company) route for your blog (turning your blog into a business) and if things continue to head in the direction that I am so far this will definitely be something I do down the line for TentBlogger.

Some Final Thoughts:
As I mentioned before, I ultimately went with personal/family insurance and that’ll be just fine for now as I coordinate my efforts with my team and as my blogging business grows, but it’s something to consider as an option as you do your research.

Ultimately you have to spend the time and energy to do the research and get all the information that you need to make the very best decision. For myself and my family (of 4) not having insurance was not an option as so I needed to make sure that I could adequately supply our needs comprehensively.

Just make sure you do the math, especially as you get closer to perhaps making that jump into professional blogging and make sure that your blog won’t hold you back (or down) financially as you take that leap of faith! A few bullet-point ideas to capture:

Do the math! Make sure you can afford it!
Start today, especially if you’re considering moving into full time blogging. Don’t make the decision after you jump off the cliff!
Do your research, it pays big time.
Talk with your existing employer about continuing coverage options.
Trust your existing network and get a trusted raeferral if you can. Ask around. A lot.
Get multiple quotes, consider all options.
Do the math, again.
Good luck, and please feel free to add to this in the comment section if you know more about this than I do!

Technique may improve detection of breast tumors

About 1 out of every 8 women nationwide will develop invasive breast cancer at some point in their lives. It is the second most common type of cancer to affect women. Detecting breast cancer as early as possible is crucial for increasing the chance of survival. However, many women avoid getting screened with the current breast cancer screening method, mammography. Mammography can be uncomfortable or painful. Mammograms also don’t always reveal early tumors in denser breast tissue.

Researchers have been developing a new method for detecting breast cancer called photoacoustic computed tomography (PACT). The technique uses harmless pulses of laser light to penetrate the breast tissue. This causes a type of sound wave called photoacoustic waves to spread through the tissue. These waves can be measured by sensors surrounding the breast. Blood vessels react to the light differently, providing contrast that allows PACT to form clear images of the breast’s blood vessel network. This approach can be used to spot tumors because tumor growth depends on blood vessels.

Previous forms of PACT have been limited by long scan times and other factors that lower image quality. Recently, a research team led by Dr. Lihong V. Wang at the California Institute of Technology developed a system called single-breath-hold PACT (SBH-PACT) that overcomes these limitations. The work was supported by NIH’s National Institute of Biomedical Imaging and Bioengineering (NIBIB) and other NIH components. Results were published in Nature Communications on June 15, 2018.

Internal vascular structure of a human breast
Image of the blood vessels in a human breast created with the PACT photoacoustic imaging technique. Lihong Wang, Caltech
To test the technique, the researchers enrolled one healthy volunteer and seven female patients with breast cancer in a clinical study. The participants had a range of skin pigmentations and breast sizes. For the scan, a soft agar pillow was used to compress the women’s breast to her chest while she laid down. A laser was shone through the breast from beneath the bed. Sensors surrounding the breast detected the resulting photoacoustic waves, and this data was used to map the blood vessels within. This system generated 2-D or 3-D images of the entire breast while the women held their breath for 15 seconds.

In the healthy volunteer, SBH-PACT produced a clear 3-D image of the blood vessel network throughout the entire breast. In the patients with breast cancer, SBH-PACT revealed eight of the nine tumors using the higher blood vessel densities of the tumors. The team was able to detect the ninth tumor using SBH-PACT to measure “elastographic” changes in breast tissue. Breast tumors are less elastic than normal breast tissue, so regions that changed less during breathing indicated tumors. This measurement could be taken in 2-D mode in about ten seconds.

Both blood vessel density and tissue compliance were measured with the SBH-PACT system in about 30 seconds. Together, these two measurements can provide a quick and safe method to detect breast cancer. However, trials with more women are needed to confirm these findings. A company founded by Wang has licensed the technology and is now planning larger studies.

“Because of the detailed images created by PACT, we are looking at other uses such as assessment of the blood vessel damage in diabetics,” Wang says. “The severe vascular damage and death of leg and foot tissues in diabetics is a major health problem that could be significantly improved by early detection and treatment.”

Editing T cell genomes without viruses

Two T cells that have been altered by using CRISPR and electroporation.
Researchers used CRISPR and a jolt of electricity to get DNA inside T cells. The glowing ring of green demonstrates how DNA can be targeted to specific structures in a cell. Alex Marson, UCSF, Nature
T cells are an important part of the immune system. They help protect the body from infection and can also help fight cancer. Researchers have been working for years to genetically alter T cells to target specific types of cells for fighting cancer and other diseases. Past methods have used viruses (viral vectors) to insert DNA into T cells. However, the viral vectors used in FDA-approved T cell therapies can’t be used to insert genes into specific genomic sites. Using viral vectors to reprogram T cells can also be a difficult and expensive process.

CRISPR-Cas9 is a genomic engineering technology that allows DNA to be inserted, removed, or changed at particular locations in the genome. It’s one of the faster, cheaper, more accurate, and more efficient genome editing methods. To investigate whether human T cell function can be reprogrammed using CRISPR without viral vectors, a team led by Dr. Alex Marson at the University of California, San Francisco, tested a method called electroporation to deliver the CRISPR-Cas9 system and DNA in human T cells. The research, which was supported by several NIH components, was published in Nature on July 11, 2018.

Electroporation uses a pulse of electricity to get DNA or other molecules inside the cell. The researchers tested and refined their electroporation technique using T cells with a combination of CRISPR-Cas9 ribonucleoprotein and the gene for green fluorescent protein (GFP). They confirmed the presence of GFP in the cells and optimized the technique to minimize the impact on the cells and increase its efficiency.

They next tested their system by targeting different sections of the genome. They fused GFP to different genes. Using confocal microscopy, they tracked the resulting GFP fusion proteins and confirmed that they were all located in their proper, distinct locations within the cell. They found that normal gene regulation mechanisms still worked for at least one of the tested genes.

The team showed that they could simultaneously modify one, two, or three genes at a time. The researchers also analyzed possible off-target effects. They found that the genes rarely reached sites that weren’t specifically targeted. They showed that certain techniques could nearly eliminate these off-target effects.

Finally, the team tested whether the system could correct a specific gene mutation involved in an autoimmune disease. They identified a family with a loss-of-function mutation in the IL-2α receptor, which is important for proper T cell function. Using cells from the family members with the gene mutation, the researchers corrected two specific defects in the gene and showed that the changes improved the receptor’s function in T cells.

The researchers also showed they could replace large sections of DNA in T cells to reprogram the antigen receptor—the part of the T cell that identifies and targets diseased cells. They compared T cells reprogrammed without viral vectors to virally reprogrammed cells in mice. Both types of reprogrammed cells located cancer cells and accumulated in tumors to similar degrees.

“This is a rapid, flexible method that can be used to alter, enhance, and reprogram T cells so we can give them the specificity we want to destroy cancer, recognize infections, or tamp down the excessive immune response seen in autoimmune disease,” Marson says.

How night shifts disrupt metabolism

An urban landscape at night that shows lights in office buildings, suggesting people at work.
Being awake at night and asleep during the day can disrupt the rhythms of certain metabolic pathways. Pranodhm/iStock/Thinkstock
You wake up, feel hungry, and fall asleep each day around repeating 24-hour “circadian” cycles controlled by your body’s internal clocks. These clocks are synchronized by a central pacemaker in the brain. Cycles of light and dark are important for the function of the brain’s master clock. Other cycles, such as the behavioral activities of eating and fasting or sleeping and waking, are important for peripheral clocks in the liver, gut, and other tissues.

When you stay awake all night or otherwise go against natural light cycles, your health may suffer. Long-term disruption of circadian rhythms has been linked to obesity, diabetes, and other health problems related to the body’s metabolism.

Previous studies have shown that some metabolites—the products of metabolism—in blood can have daily rhythms. An international research team led by Drs. Hans P. A. Van Dongen and Shobhan Gaddameedhi at Washington State University investigated whether disruptions in these rhythms are influenced by the central pacemaker in the brain or reflect behavioral activities, such as working the night shift. The study was funded in part by NIH’s National Institute of Environmental Health Sciences (NIEHS). Results were published online in the Proceedings of the National Academy of Sciences on July 10, 2018.

Ten men and four women, aged 22 to 34 years, stayed at a research lab for one week. Half had a night-shift sleep pattern for three days and half had a day-shift pattern. The night-shift pattern causes the central pacemaker and behavioral rhythms to be at odds. After three days, the volunteers were kept awake for one day in a constant routine with a constant level of temperature and light. They received identical snacks every hour and provided blood samples every three hours.

The research team found only small differences in the day-shift and night-shift patterns for melatonin and cortisol, which mark the activity of the brain’s master clock. This finding suggests that the master clock is resistant to influence from the night-shift pattern.

The team analyzed the levels of 132 metabolites during the 24-hour constant routine. About half (65) of the metabolites had a significant daily rhythm. Of these, 27 had a significant 24-hour rhythm for both sleep patterns. Only three of these metabolites (taurine, serotonin, and sarcosine) kept the same peak time, similar to the master clock markers melatonin and cortisol. The other 24 showed a 12-hour shift in rhythm for the night-shift pattern.

The researchers noted that the particular metabolites and pathways affected by the night-shift sleep pattern relate to the liver, pancreas, and digestive tract. These findings suggest that night-shift sleep patterns can disrupt certain metabolite rhythms and the peripheral clocks of the digestive system without affecting the brain’s master clock.

“No one knew that biological clocks in people’s digestive organs are so profoundly and quickly changed by shift work schedules, even though the brain’s master clock barely adapts to such schedules,” Van Dongen says. “As a result, some biological signals in shift workers’ bodies are saying it’s day while other signals are saying it’s night, which causes disruption of metabolism.”

Further research is needed to better understand the role of these metabolic pathways in obesity, diabetes, and other medical conditions for which shift workers are at increased risk.

Early family experience affects later romantic relationships

Learning how to form and sustain happy and healthy romantic relationships is a key skill for young adults. Such relationships are based on feelings of love, effective problem-solving, and the absence of physical and verbal violence. The ability to develop a healthy relationship can be influenced by the experiences people have had within their own families. However, the ways in which the family environment influences interpersonal skills and romantic relationships aren’t well understood.

A team of researchers led by Penn State graduate student Mengya Xia set out to explore how interpersonal skills and family factors affect romantic relationships. They examined data from a long-term study on preventing substance use among more than 10,000 youths in rural and semi-rural communities in Pennsylvania and Iowa. A randomly selected set of nearly 2,000 participated in a later follow-up project when they were young adults. For this analysis, the team included the 974 participants between 18 and 21 years old who were in a steady romantic relationship. The study was supported by NIH’s National Institute on Drug Abuse (NIDA) and National Institute of Child Health and Human Development (NICHD). The results were published in the July 2018 issue of Journal of Youth and Adolescence.

The participants were surveyed four times. In grades 6, 7, and 9, they were asked about their assertiveness, positive engagement with their families, family climate, and effectiveness of their parents’ discipline methods. When they were between 18 and 21, they were asked to rate the violence levels, problem-solving skills, and amount of love they felt in their romantic relationships.

The researchers found that young adults from families that were cohesive, organized, and without much conflict were less likely to be in romantic relationships with violence or poor problem-solving. However, neither the family climate nor the parenting practices were linked to feelings of love in the relationships.

Family factors also seemed to affect specific interpersonal skills. More effective parenting and a positive family climate appeared to increase the participants’ assertiveness—the ability to respectfully advocate for their needs in a relationship and have positive interactions with their families.

The influences seemed to go both ways. Participants who had positive family engagement at the start of the study reported later in childhood that they experienced more effective parenting. Assertiveness in childhood also predicted later reports of more effective parenting but did not affect family climate.

This study suggests that adolescents who grow up in positive family climates with effective parenting are more likely to have healthy romantic relationships as young adults. In addition, adolescents who are more assertive and behave positively with their families also help create a positive family climate.

“The family relationship is the first intimate relationship of your life, and you apply what you learn to later relationships,” Xia says. “It's also where you may learn how to constructively communicate—or perhaps the inverse, to yell and scream—when you have a disagreement.”

A better understanding of the family dynamics that affect adult interactions could lead to more effective strategies for improving romantic relationships. However, this study included mostly white families in rural and semi-rural areas—and also more females participated than males. More diverse populations will be needed to confirm and expand on the findings.

How drugs could repair damage from multiple sclerosis

Oligodendrocyte with nerve cell
Illustration of an oligodendrocyte, right, creating a myelin coating around a nerve cell extension. Damage to myelin can affect communication between nerve cells. Ralwel/iStock/Thinkstock
Multiple sclerosis is an autoimmune disease in which the body’s own immune system mistakenly attacks the lining of the nerves in the brain and spinal cord. When this insulating lining, called myelin, is damaged, communication between nerve cells can be interrupted. This leads to muscle weakness, problems with coordination and vision, and other symptoms of the disease.

Experts estimate that almost half a million people nationwide live with multiple sclerosis. Existing drugs can relieve symptoms for a while by calming the immune system. But in most people, the disease gets worse over time. If scientists can develop drugs that promote myelin repair in people, the damage caused by multiple sclerosis could potentially be reversed.

In previous research, a team led by Dr. Paul Tesar at Case Western Reserve University and Dr. Robert Miller at George Washington University found that miconazole, an antifungal drug, activated stem cells and repaired myelin damage in mice. The researchers, joined by Dr. Drew Adams from Case Western Reserve, wanted to understand exactly how this drug—and others that have been discovered—encourage myelin repair. The study was funded by NIH’s National Institute of Neurological Diseases and Stroke (NINDS) and other NIH components. Results were published on July 25, 2018, in Nature, along with a companion methods paper in Nature Methods.

The team used a series of laboratory techniques to examine how drugs interact with the molecules in the body that are involved in myelin production. They found that miconazole and eight other related drugs all blocked an enzyme called CYP51. Blocking CYP51 encouraged stem cells to form new oligodendrocytes. These are the cells that create the myelin coatings around nerve cells.

CYP51 is part of the molecular pathway that produces cholesterol. The researchers discovered that blocking two other enzymes in that pathway also promoted oligodendrocyte production.

The boost in oligodendrocyte production appeared to be due to buildup of a specific type of cholesterol precursor (called 8,9-unsaturated sterols) when any of the three enzymes was blocked. When the researchers treated stem cells with 8,9-unsaturated sterols, they saw oligodendrocyte production rise.

The team next screened over 3,000 approved drugs and other small molecules for their ability to promote oligodendrocyte production. The top ten all caused a buildup of 8,9-unsaturated sterols.

When tested on human stem cells grown in the laboratory, drugs or genetic manipulations that targeted any one of the three enzymes caused oligodendrocytes to form and start laying down myelin. In mice with damage to myelin in their spinal cords, injection of drugs that targeted one of the enzymes caused restoration of myelin in the damaged tissue.

“We were shocked to find that almost all of these previously identified molecules share the ability to inhibit specific enzymes that help to make cholesterol. This insight reorients drug discovery efforts onto these novel, druggable targets,” Adams says.

The researchers have formed a company to build on these findings and develop therapeutics to promote myelin repair.